文章基本信息

标题：The Effect of Zaldaride Maleate, an Antidiarrheal Compound, on Acetylcholine-Induced Intestinal Electrolyte Secretion
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作者：Nobuo AIKAWA ; Nobuyuki KISHIBAYASHI ; Akira KARASAWA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2000
卷号：23
期号：11
页码：1377-1378
DOI：10.1248/bpb.23.1377
出版社：The Pharmaceutical Society of Japan
摘要：The effect of zaldaride on acetylcholine-induced colonic electrolyte secretion was examined. The short-circuit current response to acetylcholine was partially reduced by tetrodotoxin, a neuronal blocker, and was completely inhibited by atropine, an acetylcholine M receptor antagonist, in the rat colonic preparations. The tetrodotoxin sensitive effect was significantly inhibited by zaldaride, whereas the tetrodotoxin insensitive effect was not affected. Acetylcholine release from synaptosomes of submucosal nerves of guinea-pig colon was significantly reduced by zaldaride. Zaldaride may reduce colonic electrolyte secretion by acetylcholine due to the inhibition of acetylcholine release from synaptosomes of colonic submucosal nerves.
关键词：zaldaride maleate;acetylcholine release;short-circuit current (Isc);calmodulin