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标题：AN ACUTE AND FOCAL OSTEOPENIA MODEL USING OVARIECTOMIZED RATS : A RAPID DETECTION OF THE PROTECTIVE EFFECT OF SALMON CALCITONIN
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作者：Hiromichi NAKAMUTA ; Minoru SASAKI ; Masaki ICHIKAWA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1993
卷号：16
期号：3
页码：325-327
DOI：10.1248/bpb.16.325
出版社：The Pharmaceutical Society of Japan
摘要：A screening method for anti-osteoporotics using ovariectomized rats was designed using a compact method to monitor the bone density. It was found that ovariectomy (OVX) of Wister female rats (11 weeks old) induced acute and focal osteopenia within 2 weeks, which responded well to intermittent salmon calcitonin (SCT : 5 and 20 U/kg, s.c., every other day) employed as the standard anti-osteoporotic and injected up to 4 weeks with or without a delay of 2 weeks after OVX.
关键词：osteopenia;salmon calcitonin;ovariectomy