文章基本信息

标题：CHEMICAL AND BIOLOGICAL DEGRADATION OF 5-FLUOROURACIL PRODRUGS HAVING HIGH SERUM ALBUMIN BINDING POTENCIES
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作者：Yasuo SUDA ; Kenji SHIMIDZU ; Masao SUMI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1993
卷号：16
期号：3
页码：322-324
DOI：10.1248/bpb.16.322
出版社：The Pharmaceutical Society of Japan
摘要：In order to understand the fundamental structural features which yield both high serum albumin binding potency and desired property as a prodrug, the derivatization was performed at N-1 or N-3 position in 5-fluorouracil. The N-3 derivatives were more stable than N-1 derivatives in vitro, whereas they were metabolized quickly in vivo. It is suggested that N-1 position should be blocked to avoid fast metabolism in vivo.
关键词：5-fluorouracil;prodrug;drug delivery system;protein binding;decomposition