文章基本信息

标题：Evaluation of Bioavailability upon Oral Administration of Phytonadione Preparations in Beagle Dogs
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作者：Tadakazu TOKUMURA ; Yuki TSUSHIMA ; Yoshiharu MACHIDA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1993
卷号：16
期号：3
页码：319-321
DOI：10.1248/bpb.16.319
出版社：The Pharmaceutical Society of Japan
摘要：Bioavailability of phytonadione was investigated after oral administration to beagle dogs. The administrations of phytonadione in a surfactant solution (preparation a) and in an oleic acid solution (preparations b) greatly increased the bioavailability of phytonadione. The AUCs of preparations a and b were about 2.5 times larger than those of commercially available tablets A and C. This result well corresponded to the results of the dissolution test previously reported. The absorption of phytonadione from the gastro-intestinal tract was affected by food and the bioavailability was largely increased under non-fasted conditions. However, a large scatter was observed in the data, and it was found that the evaluation of the bioavailability of phytonadione preparations could not be done in non-fasted animals.
关键词：phytonadione;bioavailability;beagle dog;surfactant solution;oleic acid solution;commercialy available tablet