文章基本信息

标题：Phenotypic Reversion Induced by Anthracyclines in ras Oncogene-Expressed Cells ; Structure-Activity Relationships
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作者：Toshie KANBE ; Kayoko S. TSUCHIYA ; Makoto HORI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1994
卷号：17
期号：4
页码：527-530
DOI：10.1248/bpb.17.527
出版社：The Pharmaceutical Society of Japan
摘要：Several antitumor anthracyclines, including those in preclinical stages, were examined for their action in reversing tumorous phenotypes of H- or K-ras 3T3 cells (NIH3T3 cells transformed by human H- or K-ras oncogene) into normal phenotypes, such as flattened cell morphology, anchorage dependent cell growth, etc. (referred to as anti-ras activity). The study elucidated relationships between the chemical structure of anthracyclines and the anti-ras activity. The human tumor cell line T24, which has a mutated H-ras gene, responded to the anthracyclines, as did K- or H-ras 3T3 cells, in respect to the phenotypic alterations. Pirarubicin was more than 4 times as active as aclarubicin in inhibiting the growth of solid tumors of K-ras 3T3 cells in nude mice, possibly reflecting a difference in anti-ras activity between the two antibiotics.
关键词：anthracycline;ras;structure-activity relationship;solid tumor;morphology;actin fiber