文章基本信息

标题：NITRIC OXIDE PRODUCTION IN MOUSE PERITONEAL MACROPHAGES ENHANCED WITH GLYCYRRHIZIN
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作者：Yoshikazu KONDO ; Fumihide TAKANO
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1994
卷号：17
期号：5
页码：759-761
DOI：10.1248/bpb.17.759
出版社：The Pharmaceutical Society of Japan
摘要：The enhancement of nitric oxide (NO) production in glycyrrhizin (GL)-induced macrophages (Mφ) in response to lipopolysaccharide (LPS) was investigated. NO production in GL-induced macrophage culture supernatants was stimulated in response to LPS (10 μg/ml) for 24-or 48-h cultures, and these levels were compared three times with the levels in saline-induced peritoneal exudate cell cultures. Furthermore, Mφ induced with proteose peptone (PP) containing GL could generate greater NO production than Mφ induced with PP alone. However, no stimulation of NO production was observed by addition of GL in the cultures of Mφ induced with thioglycollate or Bacillus Calmette Guerin. Moreover, GL-induced Mφ showed cytostasis against such tumor target cells as L 1210 and P 388 lymphoma cell lines. These observations indicate that GL can activate the Mφ in vivo system and stimulate NO production in response to LPS.
关键词：glycyrrhizin;nitric oxide;macrophage;lipopolysaccharide;antitumor activity