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标题：Antimetastatic Effect of Yeast Mannan-Bleomycin Conjugate against Mouse Lewis Lung Carcinoma
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作者：Yukiko KONNO ; Shinichi TAKAHASHI ; Ryusuke NARUSE 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1994
卷号：17
期号：5
页码：748-752
DOI：10.1248/bpb.17.748
出版社：The Pharmaceutical Society of Japan
摘要：A conjugate of bleomycin (BLM) and the mannan of bakers' yeast (Saccharomyces cerevisiae wild type strain) (WNM) was synthesized. The assay of its antimetastatic effect on Lewis lung carcinoma (3LL) implanted in C57BL/6 mice showed that this conjugate exhibited a higher antimetastatic effect and longer life-span elongation than those of free bleomycin and mannan with corresponding doses. This conjugate was also found to kill the 3LL cells in vitro. ¹⁴C-Labeled mannan-bleomycin conjugate was much more bound that ¹⁴C-labeled dextran-bleomycin conjugate to the 3LL. It was concluded that the anti-cancer mechanism of this conjugate, WNM-BLM possessed a specific binding effect to the tumor cells and exhibited a cytocidal effect on the 3LL target cells.
关键词：metastasis;mannan;bleomycin;pro-drug;Lewis lung carcinoma;Saccharomyces cerevisiae