文章基本信息

标题：Superoxide Anion-Induced Histamine Release from Rat Peritoneal Mast Cells
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作者：Masaaki AKAGI ; Yoshitaka KATAKUSE ; Nobuyuki FUKUISHI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1994
卷号：17
期号：5
页码：732-734
DOI：10.1248/bpb.17.732
出版社：The Pharmaceutical Society of Japan
摘要：We investigated the properties of superoxide anion (O^-₂)-induced histamine release from rat peritoneal mast cells using superoxide anion radicals obtained from potassium superoxide (KO₂). KO₂ elicited a rapid histamine release in a dose-dependent fashion, without lactate dehydrogenase (LDH) release. The KO₂-induced release was temperature-and energy-dependent. KO₂ rapidly increased the intracellular free Ca²⁺ concentration, accompanied by a marked increase of Ca²⁺-uptake. These findings indicate that the increase in intracellular Ca²⁺ concentration is involved in the initiation of KO₂-induced histamine release, and KO₂ could be used as an agent of O^-₂-induced biological reactions.
关键词：superoxide anion;histamine release;rat mast cell