文章基本信息

标题：Effects of 2, 5-Dimethylpyrazine on Plasma Testosterone and Polyamines-and Acid Phosphatase-Levels in the Rat Prostate
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作者：Kenji YAMADA ; Akinori SHIMIZU ; Hiroaki KOMATSU 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1994
卷号：17
期号：5
页码：730-731
DOI：10.1248/bpb.17.730
出版社：The Pharmaceutical Society of Japan
摘要：The effects of 2, 5-dimethylpyrazine (DMP) on plasma testosterone and levels of polyamines and acid phosphatase in the prostate of rat were studied. A high dose of DMP administered once daily for two weeks to juvenile male rats significantly decreased plasma testosterone and levels of polyamines and acid phosphatase in the prostate. These effects were not obtained by administration to mature male rats, and the inhibition was thus recognized to occur during the growth period. These findings suggest that a high dose of DMP inhibits the biosynthesis of polyamines and acid phosphatase in the prostate by decreasing the circulating testosterone level.
关键词：2, 5-dimethylpyrazine;plasma testosterone;polyamine;acid phosphatase