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标题：DETECTION OF 1-ACETAMINO-3-(1-NAPHTHYLOXY)-2-PROPANOL AS A NEW METABOLITE OF PROPRANOLOL
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作者：Atsuko NODA ; Yoko ONO ; Kae INOKUCHI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1994
卷号：17
期号：10
页码：1433-1435
DOI：10.1248/bpb.17.1433
出版社：The Pharmaceutical Society of Japan
摘要：1-Acetamino-3-(1-naphthyloxy)-2-propanol which is an acetyl conjugate of N-desisopropylpropranolol (AcNDP) was detected as a new metabolite of propranolol (PL) from the incubation medium of isolated rat hepatocyte system and from the urinary extracts of a patient under PL therapy as well as a healthy volunteer given PL. In the case of the hepatocyte systems, the optical selectivity of PL elimination and the metabolite formation were discussed by HPLC determination, and the effect of pretreatment by phenobarbital (PB) or 3-metylcholanthrene (3-MC) on the metabolism was also clarified.
关键词：propranolol metabolite;acetyl conjugate;rat hepatocyte;human urine