文章基本信息

标题：Ca2+ Dependency of Diadenosine 5', 5'''-p1, p4-Tetraphosphate Degradation in Dog Plasma
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作者：Ken IWATA ; Hiroshi NAKAJIMA ; Toshikiro KIMURA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1995
卷号：18
期号：5
页码：788-790
DOI：10.1248/bpb.18.788
出版社：The Pharmaceutical Society of Japan
摘要：Diadenosine 5', 5'''-p¹, p⁴-tetraphosphate (Ap4A) degradation in dog plasma was inhibited by the addition of EDTA. The Ap4A degrading activity seemed to be recovered by the addition of metal ions, Ca²⁺, Co²⁺, Cu²⁺, Mg²⁺, Mn²⁺ or Zn²⁺ to plasma in which the activity was lost by the addition of EDTA. Especially, the degradation was accelerated by the addition of Ca²⁺ to the plasma, and the degradation rate was dependent on the concentration of Ca²⁺. The results of this study suggested that the enzymatic degradation of Ap4A in dog plasma was modulated by the concentration of Ca²⁺.
关键词：Ap4A;Ca2+;degradation;EDTA;plasma;dog