文章基本信息

标题：Noninvasive Measurement of Cerebral Blood Flow and Glucose Metabolic Rate in the Rat with High-Resolution Animal Positron Emission Tomography (PET) : A Novel in Vivo Approach for Assessing Drug Action in the Brains of Small Animals
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作者：Yasuhiro MAGATA ; Hideo SAJI ; SeokRye CHOI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1995
卷号：18
期号：5
页码：753-756
DOI：10.1248/bpb.18.753
出版社：The Pharmaceutical Society of Japan
摘要：The cerebral metabolic rate of glucose (CMRglc) and cerebral blood flow (CBF) in rats were estimated noninvasively with a high-resolution animal positron emission tomography (PET) system that we recently developed. Quantifications of CMRglc and CBF were attempted with radiotracers, ¹⁸F-2-fluoro-2-deoxyglucose and ¹⁵O-water, respectively. From the data obtained with PET, the CMRglc and CBF values under pretreatment conditions were respectively calculated as 51±14μmol/min/100g and 61±7ml/min/100g under pentobarbital-anesthesia. These values were in close agreement with published data obtained with the autoradiographic technique. Moreover, and increase of 69% (mean) in CBF was detected after i.v. acetazolamide administration. The results indicate that this high-resolution animal PET scanner holds great potential for the assessment of drug-related metabolic and circulatory effects in intact and experimental animals.
关键词：animal positron emission computed tomography;^ F-2-fluoro-2-deoxy-glucose;^ O-water;glucose cerebral metabolic rate;cerebral blood flow;rat brain