文章基本信息

标题：METABOLISM OF PEPTIDE DRUGS BY THE MICROORGANISMS IN RAT CECAL CONTENTS
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作者：Hideyuki TOZAKI ; Yasuharu EMI ; Eri HORISAKA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1995
卷号：18
期号：6
页码：929-931
DOI：10.1248/bpb.18.929
出版社：The Pharmaceutical Society of Japan
摘要：The metabolism of insulin and calcitonin by microorganisms was examined in rat cecal contents. Both insulin and calcitonin were markedly degraded. Calcitonin was more susceptible to proteolysis in rat cecal contents than insulin. Calcitonin was also rapidly degraded in supernatant, while we found few degradation products of insulin. These findings suggest that care should be taken to metabolize the peptide drugs by microorganisms when they are administered to the large intestine for colon-specific drug delivery.
关键词：insulin;calcitonin;microorganism;colon-specific drug delivery