文章基本信息

标题：Gastric Cytoprotective Activity of 2-Cyclopenten-1-one and Related Compounds
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作者：Alejandra O. MARIA ; Graciela H. WENDEL ; Teresita GUARDIA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1995
卷号：18
期号：12
页码：1784-1786
DOI：10.1248/bpb.18.1784
出版社：The Pharmaceutical Society of Japan
摘要：The cytoprotective activity of the isolated functional groups of several sesquiterpene lactones is reported. Among them the highest activity is shown by α-methylen-γ-butyrolactone and 2-cyclopenten-1-one. The activity shown by those Michael acceptors with a β carbon hindered by an alkyl substituent was always lower or almost null. A three-way mechanism of action is proposed : a) reduced glutathione synthesis, b) prostaglandin synthesis and c) mucosal glycoprotein synthesis.
关键词：cytoprotection;Michael acceptor;reduced glutathione