文章基本信息

标题：Inhibitory Effect of Ginseng Total Saponins on Glutamate-Induced Swelling of Cultured Astrocytes
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作者：YeonHee SEONG ; ChangSik SHIN ; HackSeang KIM 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1995
卷号：18
期号：12
页码：1776-1778
DOI：10.1248/bpb.18.1776
出版社：The Pharmaceutical Society of Japan
摘要：The effects of ginseng total saponins (GTS) on L-glutamate-induced swelling of cultured astrocytes from rat brain were studied. Following exposure to 0.5 mM glutamate for 1 h, the intracellular water space (as measured by [³H] O-methyl-D-glucose uptake) of astrocytes increased three-fold with a morphological change : the disappearance of cellular processes. Simultaneous addition of GTS with glutamate reduced the astrocytic swelling in a dose-dependent manner. GTS at 0.5 mg/ml did not affect the viability of astrocytes for up to 18 h, which was determined by a colorimetric assay for cellular growth and survival. These data suggest that GTS prevents the cell swelling of astrocytes induced by glutamate.
关键词：ginseng total saponin;glutamate;astrocytic swelling