文章基本信息

标题：Amino Acids and Peptides. XXVI. Laminin-Related Peptide Poly (Ethylene Glycol) Hybrids and Their Inhibitory Effect on Experimental Metastasis
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作者：Koichi KAWASAKI ; Machiko NAMIKAWA ; Toyohiko MIZUTA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1995
卷号：18
期号：12
页码：1714-1717
DOI：10.1248/bpb.18.1714
出版社：The Pharmaceutical Society of Japan
摘要：Laminin-related peptide poly (ethylene glycol) hybrid, Tyr-Ile-Gly-Ser-Arg-aminopoly (ethylene glycol) was prepared by the solution method and carboxylated poly (ethylene glycol)-Tyr-Ile-Gly-Ser-Arg was prepared by the solid phase method. Their inhibitory effects on experimental tumor metastasis were examined in mice. The inhibitory effect of Tyr-Ile-Gly-Ser-Arg was significantly potentiated by hybrid formation with poly (ethylene glycol) either at amino- or carboxyl terminals of the peptide. Of the hybrids, Tyr-Ile-Gly-Ser-Arg-amino (polyethylene glycol) #6000 hybrid exhibited about 10 times more potent anti-metastatic effect than the peptide itself. The inhibitory effect of a mixture of the carboxylated poly (ethylene glycol) hybrid and Arg-Gly-Asp-aminopoly (ethylene glycol) hybrid also exhibited an inhibitory effect.
关键词：laminin;metastasis inhibitor;poly (ethylene glycol);hybrid;poly (ethylene glycol) hybrid;polymer hybrid