文章基本信息

标题：Protective Effect of Celosian, an Acidic Polysaccharide, on Chemically and Immunologically Induced Liver Injuries
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作者：Koji HASE ; Shigetoshi KADOTA ; Purusotam BASNET 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1996
卷号：19
期号：4
页码：567-572
DOI：10.1248/bpb.19.567
出版社：The Pharmaceutical Society of Japan
摘要：Hepatoprotective effect of celosian, an acidic polysaccharide isolated from the water extract of the seed of Celosia argentea, was investigated using chemical and immunological liver injury models. Celosian inhibited the elevation of serum enzyme (GPT, GOT, LDH) and bilirubin levels on carbon tetrachloride (CCl₄) -induced liver injuries in rat. In addition, the hepatoprotective effect of celosian was also observed in this model of liver injury by histopathological findings. Moreover, celosian suppressed rises in GPT or mortality on fulminant hepatitis induced by D-galactosamine/lipopolysaccharide (D-GalN/LPS) or Propionibacterium acnes/LPS in mice. These findings suggested that celosian is an active component in protection against chemical and immunological hepatitis and the activity was found to be a dose dependent.Celosian showed a concentration dependent inhibitory effect on lipid peroxide (LPO) generation in vitro. Though celosian did not reduce the release of tumor necrosis factor-α (TNF-α), it protected against recombinant human TNF-α (rhTHF-α)-induced liver injury in D-galactosamine sensitized mice.
关键词：celosian;acidic polysaccharide;Celosia argentea;hepatoprotective effect;TNF-α;lipid peroxidation