文章基本信息

标题：Effects of Liposome Size on Penetration of dl-Tocopherol Acetate into Skin
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作者：Reiko NATSUKI ; Yutaka MORITA ; Shigemitsu OSAWA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1996
卷号：19
期号：5
页码：758-761
DOI：10.1248/bpb.19.758
出版社：The Pharmaceutical Society of Japan
摘要：Liposomes were prepared from hydrogenated lecithin (H-PC) by sonication (S) or injection (I) of H-PC dissolved in ethanol containing dl-tocopherol acetate (VEA). The effects of liposomes on the dermal absorption of VEA were studied. The particle diameter of S-liposomes was smaller than that of I-liposomes. The penetration of liposomal H-PC into the skin was much higher for S-liposomes than for I-liposomes 30 min after application to the arms of healthy human volunteers and also to hairless rat back skin. The penetration of ¹⁴C-VEA into hairless rat back skin was higher from the liposomes than from free VEA, and the ¹⁴C-VEA penetration was higher from S-liposomes than from I-liposomes. ³H-Dipalmitoylphosphatidylcholine and ¹⁴C-VEA, which had been entrapped in liposomes, were not detected in plasma. H-PC inhibited the peroxidation of skin lipids. H-PC enhanced the penetration of VEA into the skin, but the degree of enhancement depended on the size of the liposomes, indicating that this liposomal characteristic was an important factor in dermal absorption and/or penetration.
关键词：liposome;topical application;tocopherol