文章基本信息

标题：Theoretical Relationship between the Post-administration Time and Plasma or Urinary Concentration of a Metabolite and the Unchanged Drug. Administration of Caffeine to Horses
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作者：Sugako ARAMAKI ; Osamu ISHIDAKA ; Etsuko SUZUKI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1996
卷号：19
期号：10
页码：1341-1346
DOI：10.1248/bpb.19.1341
出版社：The Pharmaceutical Society of Japan
摘要：In a doping test for racing horses, it is useful for the elucidation of the illegal use of drugs if one can estimate the time at which the detected drug was administered. In order to estimate the time which has elapsed after the administration of caffeine (CA) into horses, the ratios of concentration for the respective metabolites to the unchanged CA in the plasma or the urine were determined. These ratios have been known to be independent of the dose of CA. The relationship between [plasma or urinary concentration of a metabolite]/[plasma or urinary concentration of the unchanged drug] and the post-administration time of CA was expressed in a theoretical equation using pharmacokinetic parameters. When CA was administered at 2.5 mg/kg intravenously, intramuscularly or orally, all of the experimentally observed values of plasma or urinary metabolites : theophylline, theobromine and paraxantine, agreed well with the theoretical formulas, indicating that there exists a theoretical relationship between the postadministration time and the concentration ratio of the respective metabolites to unchanged CA.
关键词：administration time;caffeine;pharmacokinetics;metabolite ratio;horse;doping