文章基本信息

标题：Effects of Atropine and Loperamide on the Agitating Force and GI Transit Time in Dogs in Drug Absorption Studies
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作者：Noriko KATORI ; Nobuo AOYAGI ; Shigeo KOJIMA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1996
卷号：19
期号：10
页码：1338-1340
DOI：10.1248/bpb.19.1338
出版社：The Pharmaceutical Society of Japan
摘要：There are difficulties in drug absorption studies using dogs because of different gastrointestinal (GI) conditions between these animals and humans, including shorter intestinal transit time and strong agitation force in the GI tract. We attempted to modify the agitation force and GI transit time using atropine and loperamide. The agitation force was examined based on in vitro/in vivo correlation for two controlled release (CR) formulations of acetaminophen. Atropine treatment considerably reduced the agitating force whereas that of loperamide did not.
关键词：atropine;loperamide;acetaminophen;hydrodynamic flow;GI transit time;in vitro/in vivo relationship