文章基本信息

标题：Evaluation of Differentiation-Inducing Activity of Retinoids on Human Leukemia Cell Lines HL-60 and NB4
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作者：Yuichi HASHIMOTO ; Hiroyuki KAGECHIKA ; Emiko KAWACHI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1996
卷号：19
期号：10
页码：1322-1328
DOI：10.1248/bpb.19.1322
出版社：The Pharmaceutical Society of Japan
摘要：Retinoids, including all-trans-retinoic acid (ATRA), its isomers, and fifty synthetic retinoids (retinobenzoic acids), were tested for differentiation-inducing activity on human leukemia cell lines HL-60 and NB4. Binding activity of typical retinoids to nuclear retinoic acid receptors (RARs) was also investigated. A good linear correlation between the ED₅₀ values of differentiation-inducing activity towards HL-60 cells and those towards NB4 cells was found. Binding activities of retinoids to RARα and RARβ also correlated well to the differentiation-inducing activities.
关键词：retinoid;differentiation;induction;HL-60 cell NB4 cell;retinoic acid receptor