文章基本信息

标题：Flow Regulates Vasodilator Responses to Acetylcholine in the Isolated Canine Mesenteric Arterial Bed
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作者：Tsutomu NAKAHARA ; Kunio ISHII ; Yoshio TANAKA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1997
卷号：20
期号：5
页码：568-570
DOI：10.1248/bpb.20.568
出版社：The Pharmaceutical Society of Japan
摘要：Raising the flow rate of the perfusate from 10 to 20 ml/min significantly suppressed vasodilator responses to acetylcholine, but not to sodium nitroprusside, in the isolated canine mesenteric arterial bed. Both acetylcholine and sodium nitroprusside augmented guanosine 3', 5'-cyclic monophosphate (cyclic GMP) levels in the effluent from the vascular bed preparation, though cyclic GMP responses to these agents were not affected by raising the flow rate. These data suggest that the suppression, via raising the flow rate, of vasodilator responses to acetylcholine is not due to impaired function of the nitric oxide (NO)-cyclic GMP pathway in the mesenteric arterial bed.
关键词：flow;canine mesenteric arteria bed;acetylcholine;sodium nitroprusside;perfusion pressure;cyclic GMP