文章基本信息

标题：Prolongation of Antidiuretic Response to desmopressin Acetate by Iontophoretic Transdermal Delivery in Rats
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作者：Masashi NAKAKURA ; Yasuki KATO ; Kunio ITO 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1997
卷号：20
期号：5
页码：537-540
DOI：10.1248/bpb.20.537
出版社：The Pharmaceutical Society of Japan
摘要：An iontophoretic drug delivery system was compared with intranasal, oral and subcutaneous delivery from a standpoint of the prolongation of the antidiuretic response to desmopressin acetate (DDAVP) in diabetes insipidus rats. Iontophoretic delivery was comparable to the nasal route at a dose about five higher than the nasal route dose, and was 2 to 3 times as effective as the oral route. Effect of dose and duration of current application on the prolongation of the response to DDAVP was also investigated in order to find the effectiveness of the iontophoresis. The antidiuretic response to DDAVP delivered by iontophoresis indicated a dose-dependent prolongation and was prolonged up to about 14 h with the increase of the duration of current application; when a pulsed direct current at 0.1 mA was passed for about 1 h, the response to DDAVP was prolonged for about 9 h. DDAVP in the anodic donor steeply decreased with the application for 1 h, and the gradually decreased. We suggest that the antidiuretic response to DDAVP can be effectively controlled by regulating the absorption of DDAVP at the short-term iontophoresis eather than prolonged treatment.
关键词：iontophoresis;desmorpressin acetate;skin;permeability;rat