文章基本信息

标题：Inhibition of the Metallo-β-lactamase Produced from Serratia marcescens by Thiol Compounds
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作者：Masafumi GOTO ; Tatsuya TAKAHASHI ; Fumiko YAMASHITA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1997
卷号：20
期号：11
页码：1136-1140
DOI：10.1248/bpb.20.1136
出版社：The Pharmaceutical Society of Japan
摘要：Low molecular weight thiol compounds have been found to be strong inhibitors of metallo-β-lactamase (IMP-1) produced by Serratia marcescens TN9106, which was expressed by Echerichia coli JM109 cells. Mercaptoacetic acid and 2-mercaptopropionic acid strongly and competitively inhibited IMP-1 with K_i of 0.23 and 0.19 μM, respectively. 2-Mercaptoethanol reversibly inhibited IMP-1 but did not show simple competitive inhibition.
关键词：metallo-β-lactamase;inhibition;inhibitor;thiol compound;mercaptoacetic acid