文章基本信息

标题：Toxic Interactions between Disopyramide and Propranolol in Chick Embryos
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作者：Yuji YOSHIYAMA ; Takashi SUGIYAMA ; Hiroyuki MIYAZAKI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1997
卷号：20
期号：12
页码：1310-1312
DOI：10.1248/bpb.20.1310
出版社：The Pharmaceutical Society of Japan
摘要：The toxic interaction between disopyramide and propranolol were studied in chick embryos. Fertilized eggs of White Leghorns were incubated and investigated. Disopyramide with and without propranolol was injected into the air sac of a fertilized egg on the 16th day of incubation. Electrocardiograms (ECGs) were recorded 0 to 60 min after the injection. After each drug injection alone, the heart rate was not different compared with control. However, the heart rate was significantly decreased by combination with disopyramide and propranolol. In addition, arrhythmia was produced by disopyramide 1.0 mg/egg alone and in combination with propranolol. These findings indicate that the interaction between disopyramide and propranolol has a marked influence on the heart rate in chick embryos.
关键词：toxic interaction;disopyramide;propranolol;chick embryo;electrocardiogram