文章基本信息

标题：Inhibitory Effects of a Nitric Oxide Synthase Inhibitor, NG-Nitro-L-arginine Methyl Ester (L-NAME), on 2-Deoxy-D-glucose-Induced Hyperglycemia in Rats
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作者：Yumi SUGIMOTO ; Jun YAMADA ; Tomoko YOSHIKAWA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1997
卷号：20
期号：12
页码：1307-1309
DOI：10.1248/bpb.20.1307
出版社：The Pharmaceutical Society of Japan
摘要：The inhibitory effects of a potent nitric oxide (NO) synthase inhibitor, N^G-nitro-L-arginine methyl ester (L-NAME), on 2-deoxy-D-glucose (2-DG)-induced hyperglycemia were investigated in rats. L-NAME significantly inhibited 2-DG-induced hyperglycemia, although N^G-nitro-D-arginine methyl ester (D-NAME) did not affect it. A similar NO synthase inhibitor, N^G-monomethyl-L-arginine (L-NMMA), also inhibited 2-DG-induced hyperglycemia. The antagonistic effects of L-NAME are unrelated to the cholinergic system, since the muscarinic receptor antagonist scopolamine did not affect 2-DG-induced hyperglycemia. The neuronal NO synthase inhibitor 7-nitroindazole (7-NI) did not reduce 2-DG-induced hyperglycemia, but rather enhanced it. Our results suggest that NO may be involved in glucose homeostasis and that the inhibitory effects of L-NAME on 2-DG-induced hyperglycemia are not related to muscarinic receptors or neuronal NO synthase.
关键词：nitric oxide;NG-nitro-L-arginine methyl ester (L-NAME);2-deoxy-D-glucose;blood glucose;rat