文章基本信息

标题：Potentiation of Pirarubicin Activity in Multidrug Resistant Cells by Rifampicin
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作者：Shinobu FURUSAWA ; Shinya NAKANO ; Jianghong WU 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1997
卷号：20
期号：12
页码：1303-1306
DOI：10.1248/bpb.20.1303
出版社：The Pharmaceutical Society of Japan
摘要：The effect of the anti-tuberculosis drug rifampicin on pirarubicin activity was investigated in multidrug-resistant cells overexpressing P-glycoprotein. Rifampicin increased the sensitivity of pirarubicin to anthracycline-resistant mouse leukemic P388 cells and significantly enhanced the cytotoxicity and intracellular accumulation of pirarubicin in resistant cells, but had no effect in parent cells. By contrast, two other rifamycins, rifamycin B and SV, had no effect on pirarubicin accumulation in resistant cells. Rifampicin also enhanced pirarubicin-induced apoptosis and G₂/M blockade on the cell cycle in resistant cells. These results show that rifampicin enhances the cytotoxic action of pirarubicin in resistant cells, at least partly via the inhibition of cellular pirarubicin efflux.
关键词：rifampicin;pirarubicin;multidrug-resistant cell;cytotoxicity;apoptosis;cell cycle