文章基本信息

标题：Anti-proliferative Effect of Toremifene and Tamoxifen on Estrogen Receptor-lacking Anaplastic Thyroid Carcinoma Cell Lines
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作者：Tohru KISHINO ; Masatoshi WATANABE ; Masayuki KIMURA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1997
卷号：20
期号：12
页码：1257-1260
DOI：10.1248/bpb.20.1257
出版社：The Pharmaceutical Society of Japan
摘要：The antitumor effects of toremifene were studied in vitro using 10 anaplastic thyroid carcinoma cell lines and were compared with those of tamoxifen. The antitumor effect of toremifene was dose-dependent and the IC₅₀ values for these cell lines ranged 20.1-58.5 μM. Although the cell lines expressed multidrug resistance gene mRNA, multidrug resistance-associated protein gene mRNA and insulin-like growth factor-1 (IGF-1) receptor mRNA to various degrees, nine of them lacked estrogen receptor expression as evaluated by immunocytochemistry. These data indicate that toremifene, as well as tamoxifen, is cytolytic at relatively high doses for multidrug-resistant anaplastic thyroid carcinoma cell lines.
关键词：toremifene;anaplatic thyroid carcinoma;estrogen receptor;multidrug resistance;insulin-like growth factor-1 (IGF-1) receptor