文章基本信息

标题：An Antivirally Active Sulfated Polysaccharide from Sargassum horneri (TURNER) C.AGARDH
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作者：Tomomi HOSHINO ; Toshimitsu HAYASHI ; Kyoko HAYASHI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1998
卷号：21
期号：7
页码：730-734
DOI：10.1248/bpb.21.730
出版社：The Pharmaceutical Society of Japan
摘要：A sulfated polysaccharide was isolated from the hot water extract of a brown alga, Sargassum horneri (TURNER) C.AGARDH. Fucose was detected as the main component sugar of this polysaccharide. This compound showed potent antiviral activity against herpes simplex virus type 1, human cytomegalovirus and human immunodeficiency virus type 1. Time-of-addition experiments suggested that it inhibited not only the initial stages of viral infection, such as attachment to and penetration into host cells, but also later replication stages after virus penetration.
关键词：Sargassum horneri;brown alga;fucan sulfate;sulfated polysaccharide;anti-HSV-1 activity