文章基本信息

标题：Effect of Dimethyl-4, 4'-dimethoxy-5, 6, 5', 6'-dimethylenedioxybiphenyl-2, 2'-dicarboxylate (DDB) on Chemical-Induced Liver Injury
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作者：Su Nyeon KIM ; Sung Yeon KIM ; Hye Kyung YIM 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1999
卷号：22
期号：1
页码：93-95
DOI：10.1248/bpb.22.93
出版社：The Pharmaceutical Society of Japan
摘要：The effects of orally administered dimethyl-4, 4'-dimethoxy-5, 6, 5', 6'-dimethylene-dioxybiphenyl-2, 2'-dicarboxylate (DDB) on the hepatotoxicity induced by carbon tetrachloride, acetaminophen or ethanlo were investigated in rats and mice. Either single or repeated DDB pretreatment (50 or 200 mg/kg) did not alter the hepatotoxicity induced by carbon tetrachloride (0.2 or 1.0 ml/kg, i.p.) in female rats as indicated by increases in the activity of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and sorbitol dehydrogenase (SDH) in serum. The hepatotoxicity of acetaminophen (350 mg/kg, i.p.) was also unaffected in male mice pretreated with DDB (50 mg/kg/d) for a week. However, DDB administration (50 mg/kg/d for 7d) decreased the hepatic fatty degeneration induced by repeated ethanol treatment (0.75 g/kg. i.p., ×2 times a day for a week) in rats as shown by the accumulation of triglycerides and cholesterol in the liver. Malondialdehyde (MDA) formation in liver homogenates was inhibited by DDB treatment. The significance of the action of DDB on alcoholic fatty liver generation in clinical sttings is discussed.
关键词：DDB;antihepatotoxicity;alcoholic fatty liver;lipid peroxidation