文章基本信息

标题：Estimation of Chemical Structure of Notopterol Metabolites
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作者：Atsushi HASEGAWA ; Hiroyoshi NAKAMURA ; Toshiko WATANABE 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1999
卷号：22
期号：7
页码：725-726
DOI：10.1248/bpb.22.725
出版社：The Pharmaceutical Society of Japan
摘要：Notopterol, 5[(2E)-5-hydroxy-3, 7-dimethyl-2, 6-octadienyloxy]psoralen showed an inhibitory effect on aminopyrine N-demetylase activity in liver microsomes. In addition, notopterol has been found to be metabolized by cytochrome P450, and two kinds of metabolites were formed from notopterol. Furthermore, specific cytochrome P450 3A4 inhibitors which were isolated from grapefruit juice had the same furocoumarin structure as notopterol. Two metabolites of notopterol were separated by HPLC, and the chemical structures of the hydroxylated metabolites were estimated by ¹H-NMR spectra and liquid chromatography-mass spectrometry.
关键词：notopterol;furocoumarin structure;grapefruit juice;^1H-NMR;cytochrome P450