文章基本信息

标题：pH-Dependent Inhibitory Effects of Angiotensin-Converting Enzyme Inhibitors on Cefroxadine Uptake by Rabbit Small Intestinal Brush-Border Membrane Vesicles and Their Relationship with Hydrophobicity and the Ratio of Zwitterionic Species
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作者：Shuji KITAGAWA ; Junko TAKEDA ; Shinji SATO 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1999
卷号：22
期号：7
页码：721-724
DOI：10.1248/bpb.22.721
出版社：The Pharmaceutical Society of Japan
摘要：The inhibitory effects of five angiotensin-converting enzyme (ACE) inhibitors on the uptake of an aminocephalosporin antibiotic, cefroxadine, by rabbit small intestinal brush-border membrane vesicles were examined in the presence of an inward H⁺ gradient. Dixon plot analysis showed that all these ACE inhibitors inhibited the uptake of cefroxadine, which is transported by a H⁺/oligopeptide transporter in the membrane, in the order of enalapril
关键词：angiotensin-converting enzyme (ACE) inhibitor;cefroxadine;small intestine;brush-border membrane vesicle;intestinal absorption