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标题：Possible Involvement of Descending Serotonergic Systems in Antinociception by Centrally Administered Elcatonin in Mice
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作者：Hiromitsu NAKAMOTO ; Yuko SOEDA ; Takahiro SEKI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1999
卷号：22
期号：7
页码：691-697
DOI：10.1248/bpb.22.691
出版社：The Pharmaceutical Society of Japan
摘要：To elucidate the mechanisms of analgesic action of elcatonin, a synthetic analog of eel calcitonin, the effect of centrally injected elcatonin on acetic acid-induced writhing behavior was examined in mice. Intracisternal or intracerebroventricular injection of elcatonin significantly inhibited acetic acid-induced writhing behavior, while the intrathecal injection of elcatonin did not inhibit it. The inhibitory effect of intracisternal elcatonin was significantly attenuated by subcutaneous pretreatment with methysergide and (±)-propranolol or by intrathecal pretreatment with methysergide, (±)-propranolol, 1-(2-methoxyphenyl)-4-[4-(2-phthalimido) butyl]-piperazine hydrobromide (NAN-190) and granisetron, but not with (±)-atenolol or butoxamine. Further, the depletion of spinal 5-hydroxytryptamine (5-HT, serotonin) by pretreatment with 5, 7-dihydroxytryptamine (5, 7-DHT) significantly attenuated the inhibitory effect of intracisternally injected elcatonin on acetic acid-induced writhing behavior. These results suggest that the inhibitory descending serotonergic systems may be involved, through 5-HT_1A and 5-HT₃ receptors, in the production of an antinociceptive effect by centrally injected elcatonin.
关键词：elcatonin;antinociception;serotonergic system;5-HT1A receptor;5-HT3 receptor;writhing behavior