文章基本信息

标题：Transport and Recognition of Aminopeptidase-Resistant Cellobiose-Coupled Tyrosylglycylglycine by Intestinal Na+/Glucose Cotransporter (SGLT1) : Recognition of Suger Conjugates by SGLT1 Is Much Less Restricted than Transport
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作者：Takashi MIZUMA ; Norio SAKAI ; Katsura HAGI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1999
卷号：22
期号：8
页码：876-879
DOI：10.1248/bpb.22.876
出版社：The Pharmaceutical Society of Japan
摘要：Transport and recognition of aminopeptidase-resistant cellobiose-coupled tyrosylglycylglycine (CcpTGG) by intestinal Na⁺/glucose cotransporter (SGLT1) was examined in rat small intestine. Inhibitory effect of phloridzin (SGLT1 inhibitor) on the CcpTGG transport was extremely low. Concentration dependence of the CcpTGG transport was observed, but the primary component of transport was pasisve diffusion However, CcpTGG significantly inhibited SGLT1-mediated transport, indicating its recognition by SGLT1. Other glucose-conjugates also inhibited SGLT1-mediated transport. These results indicate that recognition of sugar conjugates by SGLT1 is much less restricted than transport, and that it should be relatively easier to design SGLT1 inhibitors than SGLT1-transportable sugar conjugates.
关键词：sodium ion/glucose contransporter;SGLT1;sugar conjugate;transport;recognition