文章基本信息

标题：Dependence of Estrogenic Activity on the Shape of the 4-Alkyl Substituent in Simple Phenols
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作者：Yuko YAMAKOSHI ; Yuko OTANI ; Shinya FUJII 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2000
卷号：23
期号：2
页码：259-261
DOI：10.1248/bpb.23.259
出版社：The Pharmaceutical Society of Japan
摘要：The ability of certain chemicals to mimic the effects of natural steroid hormones and their potential to disrupt the delicate balance of the endocrine system in animals has attracted much interest in recent years.Alkylphenolic chemicals have been reported to be weakly estrogenic. Estrogen receptor (ER) binding is primarily the result of interaction of the receptor with both a phenolic residue, and a hydrophobic pharmacophore. We have prepared and screened various phenols having a bulky 4-alkyl group, which may interact hydrophobically with the receptor, for estrogenic activity by using a previously described reporter gene assay employing COS-1 cells transfected with rat ERα-expression plasmid and an appropriate reporter plasmid. Some of the tested compounds, such as 4-(1-adamantyl)phenol and 4-cycloalkylphenols, exhibited much more potent activity than the typical estrogenic alkylphenol, 4-tert-octylphenol.
关键词：estrogen;hydrophobic interaction;structure-activity relationship;reporter gene assay