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标题：Differentiation-Inducing Effect of Magnolialide, a 1β-Hydroxyeudesmanolide Isolated from Cichorium intybus, on Human Leukemia Cells
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作者：Kyung-Tae LEE ; Joo-Il KIM ; Hee-Juhn PARK 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2000
卷号：23
期号：8
页码：1005-1007
DOI：10.1248/bpb.23.1005
出版社：The Pharmaceutical Society of Japan
摘要：Cichorium intypbus contains two 1β-hydroxyeudesmanolides, magnolialide and artesin, together with several constituents. Magnolialide inhibits the growth of several tumor cell lines and appears to induce differentiation of human leukemia HL-60 and U-937 cells to monocyte/macrophage-like cells. Another 1β-hydroxyeudesmanolide, artesin, and other consitutents were inactive. The content of magnolialide was shown to be highest in the leaves of Inje cultivar among the cultivars investigated in this study.
关键词：Magnolialide;1β-hydroxyeudesmanolide;growth-inhibitory activity;differentiation;leukemia cells;Cichorium intybus