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标题：Antifungal Activity of Hinokitiol-Related Compounds on Wood-Rotting Fungi and Their Insecticidal Activities
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作者：Yoshihiko INAMORI ; Yoshikazu SAKAGAMI ; Yasuhiro MORITA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2000
卷号：23
期号：8
页码：995-997
DOI：10.1248/bpb.23.995
出版社：The Pharmaceutical Society of Japan
摘要：Hinokitiol (β-thujaplicin), β-dolabrin and γ-thujaplicin isolated from Thujopsis dolabrata SIEB, et ZUCC. var hondai MAKINO showed antifungal activities against all of the wood-rotting fungi examined. The antifungal activity of three compounds on Daedalea dickinsii IFO-4979 was especially strong, their mininum inhibitory concentration (MIC) values being 0.2 μg/ml. Their antifungal activities on D. dickinsii IFO-4979 were as high as that of amphotericin B used as a positive control. Three compounds had strong insecticidal activities on Tyrophagus putrescentiae [50%-lethal concentration (LC₅₀ : g/m²) 0.25 in hinokitiol, 0.02 in β-dolabrin and γ-thujaplicin]. Their insecticidal activities were higher than that of N, N-diethyl-m-toluamide (DEET, LC₅₀ : 1.46 g/m²) used as a positive control. Three compopunds also showed strong insecticidal activity on Coptotermes formosanus [LC₅₀ (g/m²) 0.07 in hinokitiol, 0.05 in β-dolabrin and γ-thujaplicin], although their insecticidal activities were much lower than that of commerical chloropyrifos (LC₅₀ : 0.00016 g/m²).
关键词：hinokitiol;β-dolabrin;γ-thujaplicin;antifungal activity;wood-rotting fungus;insecticidal activity