文章基本信息

标题：CHANGES OF SENSITIVITY TO ADRENALINE ON THE NITROGLYCOL POISONED MICE
本地全文：下载
作者：Hiroshi YOSHIKAWA
期刊名称：Industrial Health
印刷版ISSN：0019-8366
电子版ISSN：1880-8026
出版年度：1965
卷号：3
期号：3-4
页码：86-90
DOI：10.2486/indhealth.3.86
出版社：National Institute of Occupational Safety and Health
摘要：The sensitivity of mice poisoned subclinically with nitroglycol to administered adrenaline was investigated, especially that of mice that had been kept free from nitro-glycol for a certain period after daily nitroglycol injections. Mice received daily subcutaneous injection of 100 mg/kg of nitroglycol for 14 days. During and after nitroglycol treatment, adrenaline of 2 mg/kg was injected daily for 3 days. The mortality rate of mice to adrenaline increased temporarily at an early stage of the treatment, but decreased gradually with successive injection of nitroglycol and that of mice treated for 14 days were the same as non-treated mice. On the other hand, the mortality rate to administered adrenaline of mice that had been kept free from nitroglycol for 2 days after 14 days' treatment increased remarkably, but that of mice after 10 days' freedom from nitroglycol returned to the normal value again. These results indicate that abrupt cessation following long-term-administration of nitroglycol may produce the remarkable rise of sensitivity to administered adrenaline.