文章基本信息

标题：Inhibitory Effect of Polypeptide from Argopecten irradias on Mice with Transplanted H22 Hepatocarcinoma and Its Mechanism
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作者：Yuan Liu ; Jian Wang ; Yanan Xia 等
期刊名称：Advance Journal of Food Science and Technology
印刷版ISSN：2042-4868
电子版ISSN：2042-4876
出版年度：2017
卷号：13
期号：2
页码：59-67
DOI：10.19026/ajfst.13.3766
出版社：MAXWELL Science Publication
摘要：The objective of this study was to investigate the inhibitory effect of Polypeptide from Argopecten Irradias (PAI) on mice with transplanted H₂₂ hepatocarcinoma. PAI was prepared by enzymatic hydrolysis and separation and the results of its structure identification indicated that it contained five polypeptide components with molecular weights of 700-1000 Da. Forty Kunming mice were randomly divided into H₂₂ hepatocarcinoma group and low, medium and high dose PAI groups. After ig administration of normal saline and different doses of PAI for 10 days, all mice were inoculated with H₂₂ hepatocarcinoma cell suspension to establish models. After continuous gavage for 10 days, the blood was collected from the eyeball and the mice were sacrificed for index detection. It was found that the tumor inhibiting rates of PAI in three dose groups were 28.16, 41.93 and 84.00%, respectively. Compared to H 22 hepatocarcinoma group, the mutant serum p53, survivin and MDA levels of mice in three PAI-dose groups were significantly reduced ( p p 22 hepatocarcinoma cells.