文章基本信息

标题：Coral-associated bacterial extracts inhibit cellular NF-κB pathway
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作者：Edwin Oliver ; Natarajan Nandakumar ; Hanny Faibish 等
期刊名称：Cogent Environmental Science
电子版ISSN：2331-1843
出版年度：2017
卷号：3
期号：1
页码：1292865
DOI：10.1080/23311843.2017.1292865
语种：English
出版社：Taylor and Francis Ltd
摘要：Abstract Marine natural products have recently been recognized as a promising source of NF-κB inhibitors. In this study, extracts of bacterial isolates from the coral Favis sp. were screened for NF-κB modulatory capability using an NF-κB luciferase reporter gene assay. The bacterial extracts had variable effects on NF-κB activity: from the 39 extracts tested, only one exhibited significant NF-κB inhibition and two caused NF-κB up regulation. In addition, we showed that coral bacteria New-33 extract inhibits NF-κB alternative pathway subunits in a non-cytotoxic manner. HPLC analysis confirmed the presence of a low molecular mass compound and NCBI megaBLAST revealed that the New-33 16S rRNA gene sequences are similar to Vibrio mediterranei. This specific modulation of the NF-κB by alternative pathway could contribute to therapeutic implications and also raises questions about host-symbiont interaction in the marine environment.
关键词：marine natural products ; Vibrio mediterranei ; NF-κB ; host–symbiont interaction