文章基本信息

标题：Effects of dietary thylakoid intake just before diet on postprandial serum hypertriglyceridemia in rats
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作者：Ryo Otokozawa ; Hiroko Matsuda ; Kodai Kumazaki 等
期刊名称：日本食生活学会誌
印刷版ISSN：1346-9770
电子版ISSN：1881-2368
出版年度：2016
卷号：27
期号：4
页码：237-242
DOI：10.2740/jisdh.27.4_237
出版社：Japan Association for the Integrated Study of Dietary Habits
摘要：The postprandial increase in blood triglyceride levels is an independent risk factor for coronary artery disease and a large number of studies has shown that a diet rich in vegetables may provide protection against many chronic diseases. Leaf vegetables generally contain β-carotene, zeaxanthin and chlorophyll including thylakoids. In this study, we investigated the bile acid-binding capacities of thylakoids in vitro and the suppressive effects of it before the administration of a lipid meal on postprandial hypertriglyceridemia in rats using oral fat tolerance/loading tests (OFTT). Consequently, thylakoids bound bile acids in a dose-dependent manner. Following the administration of the lipid meals, increases in the serum triglycerides levels were significantly reduced in rats fed 300 mg/kg bw of thylakoids just before lipid meals. Additionally, the area under the curve showed that a high-dose thylakoids significantly inhibited the absorption of dietary fat. Moreover, the level of fecal bile acid was significantly increased although there were no significant differences in the fecal volume and fecal total lipid levels. These results suggest that thylakoid intake before eating a lipid diet induces a suppressive effect of postprandial hypertriglyceridemia to defecate bile acid and confirmed the results of the health-promoting potential dietary thylakoids. This health benefit of thylakoids could be achieved by substantially increasing the consumption of vegetables.