文章基本信息

标题：Metabolism of glycerol ether-containing lipids in dogfish (Squalus acanthias)
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作者：Donald C. Malins
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：1968
卷号：9
期号：6
页码：687-692
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：Dogfish ( Squalus acanthias ) received intrahepatic injections of either palmitic acid-1-¹⁴C or chimyl alcohol-1-¹⁴C. The lipids of the liver were then analyzed for incorporated radioactivity. The experiments with labeled palmitic acid demonstrated that fatty acids are reductively incorporated into the alkyl and alkenyl ether chains of glycerolipids. Significantly lower specific activities were found for the diacyl alk-1′-enyl ethers and diacyl glycerol ethers than for other glycerol ether-containing lipids. These compounds may therefore represent terminal points in ether-lipid metabolism. The studies with labeled chimyl alcohol indicate that dogfish liver contains enzymes that have a high capacity for oxidatively cleaving alkyl ether linkages. Furthermore, it is probable that alkyl ethers are converted directly to alkenyl ethers, possibly via a biodehydrogenation reaction.
关键词：monoacyl ; diacyl ; nonesterified ; glycerol ethers ; liver ; analysis ; uptake ; palmitic acid ; chimyl alcohol