文章基本信息

标题：Effect of p-chlorophenoxyisobutyrate (CPIB) fed to rats on hepatic biosynthesis and catabolism of ubiquinone
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作者：M. R. Lakshmanan ; W. E. J. Phillips ; R. L. Brien 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：1968
卷号：9
期号：3
页码：353-356
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：The effect of p -chlorophenoxyisobutyrate (CPIB) feeding on cholesterol and ubiquinone metabolism in rats was investigated. The results obtained from acetate-l-¹⁴C and mevalonate-2-¹⁴C incorporation studies both in vivo and in vitro confirm the results of other workers that CPIB feeding caused a metabolic block in the conversion of acetate to mevalonate, thereby inhibiting over-all steroidogenesis. Liver ubiquinone synthesis was inhibited in CPIB-fed rats, but a block in the catabolism of the ubiquinone resulted in accumulation of ubiquinone in CPIB-fed animals.
关键词：CPIB ; cholesterol ; ubiquinone ; hydrocarbon ; biosynthesis ; turnover ; rat ; liver ; acetate ; mevalonate