文章基本信息

标题：Metabolism of labeled dihydrosphingomyelin in vivo
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作者：Peter B. Schneider ; Eugene P. Kennedy
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：1968
卷号：9
期号：1
页码：58-64
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：Tritiated dihydrosphingomyelin was injected into rats, and after various time intervals the distribution of radioactivity in various organs and in the blood and urine was determined. The rate of catabolism of the administered dihydrosphingomyelin was relatively rapid, since about one-fifth of the tritium was recovered as body water after 6 hr. The liver appeared to be the principal site of metabolism of injected dihydrosphingomyelin, although other tissues were also labeled. The radioactive lipids were extracted from each organ and fractionated by chromatography. The tritium label was found in diminishing amounts in the sequence dihydrosphingomyelin, dihydroceramide, dihydrosphingosine, which suggests that the catabolism of dihydrosphingomyelin proceeds in that sequence. An extensive incorporation of label into lipids other than sphingolipids was also observed.
关键词：sphingolipids ; metabolism ; catabolism ; dihydrosphingomyelin ; ceramide ; sphingosine ; sphingosine phosphoryl choline ; sphingomyelin