文章基本信息

标题：Serum and lymph lipids in rabbits with carbon tetrachloride-induced cirrhosis of the liver
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作者：Masahiko Kotani ; Kanji Seiki ; Akira Yamashita 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：1967
卷号：8
期号：3
页码：181-184
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：Lymph flow and the composition of lymph lipids from the hepatic and thoracic ducts of rabbits with cirrhosis of the liver (induced by 46-51 intramuscular injections of a mixture of carbon tetrachloride and olive oil at 4-day intervals) have been compared with those of control animals injected with olive oil only. In cirrhotic animals, the concentration of lymph lipids was not greatly altered, but lymph flow, and consequently the hourly transport of lipids by lymph were greatly increased; the increase in transport of cholesteryl esters, free cholesterol, and phospholipids by way of the thoracic and hepatic duct lymph was particularly striking. The concentration of these lipid fractions in serum from the cirrhotic rabbits was also increased. The differences normally observed between lipid fatty acid compositions of serum and lymph disappeared in cirrhotic animals; this is interpreted as due to increased hepatic permeability to lipoproteins.
关键词：fatty liver ; cirrhosis ; rabbits ; carbon tetrachloride ; lymph ; flow ; serum ; lipid composition ; IR spectrometry ; fatty acid composition ; hepatic permeability