文章基本信息

标题：Turnover of cholesteryl esters of plasma lipoproteins in the rat
本地全文：下载
作者：Lewis I. Gidez ; Paul S. Roheim ; Howard A. Eder 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：1967
卷号：8
期号：1
页码：7-15
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：Turnover of individual classes of cholesteryl esters (classified on the basis of the degree of unsaturation of the fatty acid moiety) in rat plasma lipoproteins and liver was studied after the administration of mevalonic acid-5-³H and mevalonic acid-2-¹⁴C. The relative turnover rate was greatest in the d saturated = dienes > tetraenes. In the d > 1.063 lipoproteins, all cholesteryl esters had slower turnover rates, but tetraenes = pentaenes > dienes > monoenes = saturated. Comparisons of specific activities of individual cholesteryl ester classes of liver subcellular fractions and lipoproteins suggest that the d In the adrenal, relative rates of synthesis of cholesteryl esters are monoenes = dienes > tetraenes > trienes = pentaenes > saturated. It is concluded that cholesteryl ester turnover in the rat, as opposed to man, is determined not only by the particular lipoprotein class but also by the fatty acid moiety of the ester.
关键词：turnover ; cholesteryl esters ; plasma lipoproteins ; degree of unsaturation ; biosynthesis ; liver subfractions ; adrenals ; rat ; plasma acyltransferase