文章基本信息

标题：Evidence for centers in the central nervous system that regulate fat mobilization in dogs
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作者：Alan Goldfien ; K. S. Gullixson ; G. Hargrove 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：1966
卷号：7
期号：3
页码：357-367
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：Infusions of 2-deoxyglucose (2-DG) into intact, adrenalectomized, and adrenalectomized-hypophysectomized dogs caused increases in plasma free fatty acid (FFA) levels which could be reversed by infusing hexamethonium, or prevented by epidural anesthesia or destruction of the thoracic spinal cord. Similar infusions of 2-DG were given to adrenalectomized dogs after transection of the spinal cord. Lesions between C 4 and T 7 prevented the increase in FFA while lesions at T 8 or C 2-3 did not. These results indicate that inhibition of glucose metabolism by 2-DG causes an increase in plasma FFA by a pathway involving the sympathetic nervous system and that there are centers regulating this activity in the cervical portion of the spinal cord.
关键词：central nervous system ; fat mobilization ; hypoglycemia ; 2-deoxyglucose ; spinal cord ; hypophysectomy ; adrenalectomy ; sympathetic nervous system ; growth hormone ; sympathetic blockade ; free fatty acids ; glucose receptors ; adipokinetic factors ; chemoreceptors ; adrenal medullary secretion