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标题：In vitro esterification of cholesterol by pancreatic juice and by acetone powder extracts of small intestine: the effect of unsaturated fatty acids upon esterification with saturated fatty acids
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作者：S. N. Shah ; W. J. Lossow ; I. L. Chaikoff 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：1965
卷号：6
期号：2
页码：228-232
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：The esterification of cholesterol by rat pancreatic juice and by extracts of acetone powders of rat small intestine was studied with palmitic, stearic, oleic, linoleic, and linolenic acids. When each fatty acid was tested individually, the extent of esterification was highest with oleic acid and lowest with the two saturated fatty acids. The esterification of cholesterol with palmitic and stearic acids by the intestinal extracts and with palmitic acid by pancreatic juice was greatly increased by the addition of either oleic or linoleic acid to the incubation mixture. It is suggested that the difference between esterification of cholesterol with saturated fatty acids and esterification with unsaturated fatty acids, as well as the enhancement of the esterification with saturated fatty acids by the addition of an unsaturated fatty acid, is accounted for by micellar solubilization of cholesterol and of saturated fatty acid in the presence of an unsaturated fatty acid and bile salts.
关键词：cholesterol esters ; biosynthesis ; specificity ; saturated ; unsaturated ; pancreatic juice ; small intestine ; rat ; micellar solubilization ; bile salt