文章基本信息

标题：Lipid metabolism in pigeon aorta during atherogenesis
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作者：Hugh B. Lofland ; Daniel M. Moury ; Carl W. Hoffman 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：1965
卷号：6
期号：1
页码：112-118
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：The development of atherosclerosis has been studied in White Carneau and Show Racer pigeons. The results of analytical studies indicate that the disease process is characterized by the accumulation of various lipids, and especially of sterol esters and free sterols. By perfusion of arteries with blood serum or with tissue culture medium containing (C¹⁴-labeled acetate, significant synthesis of labeled fatty acids has been shown to occur. As the aorta becomes relatively more diseased, the synthesis of fatty acids is enhanced, and the atherosclerotic plaque itself appears to be the site of most of the synthesis. Likewise, as the aorta becomes more diseased, relatively more of the newly synthesized fatty acid becomes esterified to cholesterol. The cholesterol to which the fatty acid is esterified appears to be that which is contained within the arterial wall, and the artery appears to have the necessary enzyme systems for carrying out the esterification.
关键词：atherogenesis ; fatty acid biosynthesis ; aorta ; pigeon ; cholesterol feeding ; cholesterol ester synthesis ; esterifying enzymes