文章基本信息

标题：Structure, function, and genetics of lipoprotein (a)
本地全文：下载
作者：Konrad Schmidt ; Asma Noureen ; Florian Kronenberg 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2016
卷号：57
期号：8
页码：1339-1359
DOI：10.1194/jlr.R067314
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：Lipoprotein (a) [Lp(a)] has attracted the interest of researchers and physicians due to its intriguing properties, including an intragenic multiallelic copy number variation in the LPA gene and the strong association with coronary heart disease (CHD). This review summarizes present knowledge of the structure, function, and genetics of Lp(a) with emphasis on the molecular and population genetics of the Lp(a)/LPA trait, as well as aspects of genetic epidemiology. It highlights the role of genetics in establishing Lp(a) as a risk factor for CHD, but also discusses uncertainties, controversies, and lack of knowledge on several aspects of the genetic Lp(a) trait, not least its function.
关键词：copy number variation ; Mendelian randomization ; cardiovascular risk factor ; lipoprotein metabolism